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Kinetic barriers to [small alpha]-synuclein protofilament formation and conversion into mature fibrils
Oligomeric and protofibrillar aggregates that are populated along the pathway of amyloid fibril formation appear generally to be more toxic than the mature fibrillar state. In particular, α-synuclein, the protein associated with Parkinson's disease, forms kinetically trapped protofibrils in the pres...

Direct water-based synthesis and characterization of new Zr/Hf-MOFs with dodecanuclear clusters as IBU
Two new metal-organic framework compounds of composition [M12(μ3-O)8(μ3-OH)8(μ-OH)6(OH)6(H2O)6(APDC)6], with M = Zr and Hf denoted as M-CAU-39, containing the azopyridinedicarboxylate ion (APDC2-) as a new linker, were obtained by a water based synthesis. The crystal structure was determined from po...

Directed Assembly of Fullerene on Modified Au(111) Electrodes
Here we show a conceptual approach to realize the scanning probe based induced-assembly of fullerene (C60) molecules on top of a buffer organic adlayer at room temperature in solution environment. The realization of spatially-defined C60 assembly is attributed to modulation of substrate-molecular in...

Charge effects regulate reversible CO2 reduction catalysis
Modular but geometrically constrained ligands were used to investigate the impact of key ligand design parameters (charge and bite angle) on CO2 hydrogenation and formic acid dehydrogenation activity. These studies yielded an optimized catalyst that achieved over 118 000 turnovers in CO2 hydrogenati...

Rapid access to RNA resonances by proton-detected solid-state NMR at >100 kHz MAS
Fast (>100 kHz) magic angle spinning (MAS) Nuclear Magnetic Resonance (NMR) allows to combine the high sensitivity of proton detection with the absence of an intrinsic molecular weight limit in solid-state NMR. This technique enables observing for the first time narrow 1H NMR resonances for an RNA-p...

Change in collective motion of colloidal particles driven by optical vortex with driving force and spatial confinement
We studied the change in collective behavior of optically driven colloidal particles on a circular path. The particles are simultaneously driven by the orbital angular momentum of an optical vortex beam generated by a holographic optical tweezer. The driving force is controlled by the topological ch...

A versatile biosynthetic approach to amide bond formation
The development of versatile and sustainable catalytic strategies for amide bond formation is a major objective for the pharmaceutical sector and the wider chemical industry. Herein, we report a biocatalytic approach to amide synthesis which exploits the diversity of Nature's amide bond forming enzy...

Metal?azole fungistatic drug complexes as anti-Sporothrix spp.
The new complexes [Cu(PPh3)2(KTZ)2]NO3 (1), [Cu(PPh3)2(CTZ)2]NO3 (2), [Au(KTZ)2]Cl (3), [Au(CTZ)2]Cl (4) and Pt(KTZ)2Cl2 (5) were prepared by reaction of KTZ, CTZ (where CTZ: 1-[(2-chlorophenyl)-diphenylmethyl-1H-imidazole and KTZ: cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl...

Group 2 Metal Bis(arenecarbochalcogenoate)(Crown Ether) Complexes: Isolation and Structural Analysis
A series of Group 2 metal bis(arenecarbochalcogenoato)(crown ether) complexes M(EE’CAr)2(L)(L’)x (M = Mg, Ca, Sr, Ba; Ar = aryl; E = S, Se; E’ = O, S; L = H2O or THF; L’ = 15-crown-5, 18-crown-6) were synthesized and their structures were revealed by X-ray analyses. The two carbothioato ligands in M...

On the Degradation Pathway of Glyphosate and Glycine
The degradation in water of the most widespread herbicide, glyphosate, is still under debate. Experimental disagreements on this process exist and there are only a few theoretical studies to support any conclusions. Moreover, the relationship between glyphosate and glycine is underestimated. Besides...

Versatile coordination of acetazolamide to ruthenium(II) p-cymene complexes and preliminary cytotoxicity studies
The carbonic anhydrase inhibitor acetazolamide (AcmH2) reacted with [(η6-p-cymene)RuCl(μ-Cl)]2 to afford [(η6-p-cymene)RuCl2(κN-AcmH2)], 1A, in near-quantitative yield. In methanol, 1A exists in equilibrium with 1B, being probably a coordination isomer, as established by VT 1H-EXSY NMR spectroscopy....

Triazole vs Triazolium Carbene Ligands in the Site-Selective Cyclometallation of o-Carboranes by M(III) (M=Ir,Rh) Complexes
Ir(III) and Rh(III)-mediated site-selective cage B–H and C–H bond activation in o-carboranylmethyl derivatives has been achieved. The selectivity of the reaction is related to the electron donating properties of the ligand. 1,2,3-triazole-Derivatives use the N2 position of the triazole ring to direc...

Synthesis, Structure, Photophysical and Electrochemical Properties of Ru(II) Complexes of Arylene-Vinylene Terpyridyl Conjugates
A series of arylene-vinylene π-conjugated terpyridyl ruthenium(II) complexes, [Ru(PPh3)2Cl(tpy-C6H4-CH=CH-Ar)][PF6] (1-4; tpy = 2,2':6',2''-terpyridyl where Ar = phenyl, tolyl, 1-naphthyl and 9-anthracenyl as substituents on 4′ position of tpy) have been synthesized and characterized by multinuclear...

Origins of possible synergistic effects in the interactions between metal atoms and MoS2/graphene heterostructures for battery applications
The interactions between metals and two-dimensional materials, in particular, the adsorption energies, strongly determine the performances of rechargeable batteries. Previously, it has been demonstrated that heterostructures of two dimensional (2D) materials can lead to enhanced metal adsorptions, w...

A thermoresponsive dynamic polymer brush fabricated by the segregation of amphiphilic diblock copolymers
A highly dense polymer brush was previously fabricated by the spontaneous segregation of amphiphilic diblock copolymers in an elastomer matrix into water and a hydrophobic polymer interface and named a ‘dynamic polymer brush’. We fabricated a lower critical solution temperature (LCST)-type thermores...


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